Fri Apr 22 2022

88 articles - From Saturday Apr 16 2022 to Friday Apr 22 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Aliment Pharmacol Ther

Editorial: Lyon consensus metrics-towards personalised diagnosis of non-erosive reflux disease.

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Meta-analysis

meta-analyses and systematic reviews

Gastroenterology

Deep submucosal invasion is not an independent risk factor for lymph node metastasis in T1 colorectal cancer: a meta-analysis.

DSI is not a strong independent predictor for LNM and should be reconsidered as a sole indicator for oncologic surgery. The expanding armamentarium for local excision as first-line treatment prompts serious consideration in amenable cases to tailor T1 CRC management.

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Neurogastroenterol Motil

Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux.

A sequential treatment strategy, including head of bed elevation, prolonging dinner-to-bed time, promoting left lateral decubitus position and treatment with acid-suppressive medication is recommended for nocturnal gastroesophageal reflux symptoms. Currently, there is insufficient evidence for the use of nCPAP, hypnotics, baclofen and adding bedtime H2 receptor antagonists.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Safety of sequential biological therapy in inflammatory bowel disease: results from a tertiary referral Centre.

This study shows that the sequential use of biological therapy in IBD does not seem to convey an overall higher risk of serious infections or malignancies, but that underlying more refractory disease seems to increase this risk.

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Am J Gastroenterol

Abnormal perception of urge to defecate: an important pathophysiological mechanism in women with chronic constipation.

Abnormal urge perception was observed in 50% of women with CC, and was frequently described as abdominal sensation, supporting the concept that sensory dysfunction makes an important contribution to the pathophysiology of constipation.

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Comparative Effectiveness of Biologics for Endoscopic Healing of the Ileum and Colon in Crohn's Disease.

In this post-hoc analysis, TNFa antagonists were overall superior to vedolizumab and ustekinumab for achieving one-year EH in moderate-severe CD patients.

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Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease (PRODUCE): A Series of N-of-1 Diet Trials.

SCD and MSCD did not consistently improve symptoms or inflammation, although some individuals may have benefited. However, there are inherent difficulties in examining dietary changes that complicate study design and ultimately conclusions regarding effectiveness.

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The Role of Food in the Treatment of Bowel Disorders: Focus on Irritable Bowel Syndrome and Functional Constipation.

Finally, we discuss the available efficacy data for fiber, other dietary interventions (e. g., Mediterranean diet, gluten-free diet, holistic dietary interventions), and functional foods (e. g., kiwifruit, rhubarb, aloe, prunes, etc.) in the management of IBS and FC.

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Clin Gastroenterol Hepatol

Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multi-center Inpatient Cirrhosis Cohort.

In a multi-center inpatient cohort, admission serum metabolites, including thyroxine predicted advanced HE development independent of clinical factors. Admission low local laboratory thyroxine levels were validated as a predictor of advanced HE development in a separate cohort.

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Association of standardized radiology reporting and management of abdominal CT and MRI with diagnosis of pancreatic cancer.

In this large quasi-experimental community-based observational study, implementation standardized reporting of abdominal CT and MRI reports with clinical navigation was effective for increasing the detection and diagnosis of pancreatic cancer.

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Screening HIV patients at risk for NAFLD using MRI-PDFF and transient elastography: a European multicenter prospective study.

In a large cohort of HIV-moninfected patients at risk of NAFLD, steatosis is present in two third of cases and around 10% have AF. The CAP technique is accurate for screening steatosis in this population.

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Gut

Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis.

These findings suggest that adoptive Treg therapy might be effective in refractory UC and might open new avenues for clinical trials in PSC.

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FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression.

FOXA2 replaces FXR to maintain MRP2 expression in ALF without sepsis. Ectopic FOXA2 expression to maintain MRP2 represents a potential strategy to prevent hyperbilirubinaemia in septic ALF.

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Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

Taken together, our findings establish novel pathophysiological roles and functions for LOXL2 in PDAC, which could be potentially exploited to treat metastatic disease.

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Hepatology

Identification of the Chloride Channel, Leucine-Rich Repeat-Containing Protein 8, subfamily A (LRRC8A), in Mouse Cholangiocytes.

These results demonstrate that LRRC8A is functionally present in mouse BECs, contributes to volume-activated Cl - secretion, and therefore, may be a target to modulate bile formation in the treatment of cholestatic liver disorders.

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Neutralization and receptor usage of infectious culture derived rat hepacivirus as a model for hepatitis C.

The RHV-rn1 infectious cell culture system enables studies of humoral immune responses against hepacivirus infection. Moreover, recapitulation of the entire RHV-rn1 infectious cycle in cell culture will facilitate reverse genetic studies and the exploration of tropism and virus-host interactions.

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Racial and ethnic disparities in early treatment with immunotherapy for advanced hepatocellular carcinoma in the United States.

Immunotherapy was associated with improved OS compared to chemotherapy in advanced HCC. There are significant disparities in early access to immunotherapy, likely due to differential access to clinical trials and experimental therapies. A comprehensive approach to monitoring and eliminating racial-ethnic disparities in the management of advanced HCC is urgently needed.

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Relationship between non-alcoholic fatty liver disease and coronary artery disease: A Mendelian randomization study.

The two-sample MR analyses showed a robust association between genetically predicted NAFLD and CAD after exclusion of genetic variants that are implicated in impaired VLDL secretion.

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TRIM31 confers protection against nonalcoholic steatohepatitis by deactivating MAP3K7.

TRIM31 may serve as a promising therapeutic target for NASH treatment and associated metabolic disorders.

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Inflamm Bowel Dis

Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease.

Leucine-rich alpha-2 glycoprotein can be used in assessing endoscopic activity and is a reliable marker of endoscopic remission in CD patients. It can be an intermediate target in the treatment of CD.

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Assessment of the Degree of Variation of Histologic Inflammation in Ulcerative Colitis.

We found minimal variability between degree of inflammation among biopsy fragments within and among different colorectal segments in UC, suggesting that even a single biopsy would adequately reflect the inflammation of the entire colorectum. These findings have significant implications for the use of histology as a clinical target and trial end point in UC.

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Histological Indices and Risk of Recurrence in Crohn's Disease: A Retrospective Study of a Cohort of Patients in Endoscopic Remission.

Histological scores are valuable indicators to predict recurrence. Histological assessment of activity seems insufficient to predict CD course with most of the score evaluated, highlighting the need for new indices or adaptation of actual scores to CD specificities.

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J Crohns Colitis

Network analysis of inflammatory bowel disease research: towards the interactome.

A reductionist and fragmented approach in the study of IBD has prevailed in the previous decades, highlighting the importance of transitioning towards a more integrated interactome framework.

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The impact of vedolizumab and ustekinumab on articular extra-intestinal manifestations in inflammatory bowel disease patients: a real-life multicentric cohort study.

Vedolizumab and ustekinumab can be used safely in patients with articular extra-intestinal manifestations. Only a temporary increased risk for developing arthralgia has been observed under vedolizumab.

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J Hepatol

Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial.

In patients with mild-to-moderate fibrosis due to NASH, semaglutide with firsocostat and/or cilofexor was generally well tolerated. In exploratory efficacy analyses, treatment resulted in additional improvements in liver steatosis and biochemistry vs semaglutide alone. Given this was a small-scale open-label trial, double-blind placebo-controlled trials with adequate patient numbers to assess efficacy and safety of these combinations in NASH are warranted.

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Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma.

This study identifies early predictors of clinical response to anti-PD-1 ICB in HCC patients and offers mechanistic insights into the immune trajectories of these immune subsets that interface between response and toxicity. We also propose a new combination immunotherapy for HCC to enhance response without exacerbating irAEs.

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Neurogastroenterol Motil

Guidewire-assisted placement of water-perfused esophageal high-resolution manometry probe when gastric insertion fails: A single-center experience.

In cases of inability to traverse the EGJ, insertion of a water-perfused HRM probe using an endoscopically-placed nasogastric guidewire allows successful EGJ and esophageal peristalsis assessment. Although motility disorders are often suspected using alternative diagnostic modalities, guidewire-assisted placement of HRM may be helpful for revealing them in patients where alternative diagnostic modalities are either unavailable or inconclusive.

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Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension.

IBS-C and FABD patients show reduced TI motility and differences in luminal content compared with HCs. This potentially indicates reflux of colonic contents or delayed clearance of the TI, which alongside increased ACD may contribute to symptoms of constipation and bloating.

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Metabotropic 5-HT receptor-mediated effects in the human submucous plexus.

Background Serotonin (5-HT) is an important mediator in the gastrointestinal tract, acting on different neuronal 5-HT receptors. The ionotropic 5-HT receptors in the postsynaptic activation of human submucous neurons by 5-HT.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: response to tofacitinib is associated with high rates of long-term treatment persistence.

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Editorial: risky business. What do sufferers' perceptions of risk from interventions for irritable bowel syndrome really mean?

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Editorial: screening for hepatocellular carcinoma in NAFLD-towards abbreviated MRI alternative in patients with obesity?

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Editorial: shedding new light on extraintestinal manifestations in inflammatory bowel disease.

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Editorial: the importance of utilising gastrointestinal ultrasound via transperineal approach in ulcerative colitis-an accurate early predictor of response to treatment.

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Editorial: variceal haemorrhage-under pressure, not the probe pushing down on me.

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Gastroenterology

Presentation of the Julius M. Friedenwald Medal to Timothy C. Wang, MD, AGAF.

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Gastrointest Endosc

Outcomes after outpatient endoscopy: Can administrative data tell the whole story?

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Hepatology

Alcohol use disorder in community management of chronic liver diseases.

For those with hepatitis C or non-alcoholic fatty liver disease (NAFLD), alcohol use accelerates negative liver-related outcomes. In women, alcohol use accelerates liver damage and results in worsened liver-related mortality. Efforts to integrate AUD and liver disease care are urgently needed and can occur at several levels, with establishment of multidisciplinary ALD clinics for fully integrated co-management as an important goal.

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Portal fibroblasts: A renewable source of liver myofibroblasts.

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Prophylactic embolization of large spontaneous portosystemic shunts with TIPS: A panacea for post TIPS hepatic encephalopathy?

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Lyon consensus metrics-towards personalised diagnosis of non-erosive reflux disease: Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: risky business. What do sufferers' perceptions of risk from interventions for IBS really mean? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: screening for hepatocellular carcinoma in NAFLD cirrhosis-towards abbreviated MRI alternative in patients with obesity? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: shedding new light on extraintestinal manifestations in inflammatory bowel disease-authors' reply.

Pubmed   Journal   ReadQx 

Editorial: the importance of utilising gastrointestinal ultrasound via transperineal approach in ulcerative colitis-an accurate early predictor of response to treatment. Authors' reply.

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Letter: association between COVID-19 and inflammatory bowel disease-Authors' reply.

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Letter: association between COVID-19 and inflammatory bowel disease.

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Letter: COVID-19 outcomes and anti-TNF treatments-comprehensive evidence matters.

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Letter: COVID-19 outcomes and anti-TNF treatments-comprehensive evidence matters. Authors' reply.

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Letter: de novo infection in hepatic encephalopathy-the culprit or the victim?

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Letter: de novo infection in hepatic encephalopathy-The culprit or the victim? Authors' reply.

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Letter: the clinical course of Crohn's disease-the Sicilian experience.

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Letter: the clinical course of Crohn's disease-the Sicilian experience. Authors' reply.

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Gastroenterology

Correspondence: Failure to Achieve Target Drug Concentrations During Induction and Not HLA- DQA1*05 Carriage is Associated with Anti-Drug Antibody Formation in Patients with Inflammatory Bowel Disease - Is HLADQA1*05 gone before it's here?

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Proactive therapeutic drug monitoring of adalimumab in patients with Crohn's disease.

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Gut

Could war and the supply chain crisis affect the sustainability of gastrointestinal endoscopy and single-use endoscopes?

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Hepatology

Comment on "Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury".

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Letter to the editor: Cautious use of multistate modeling in prognosis analysis of hepatocellular carcinoma.

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Reply to the comment on "Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury".

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Reply to: Letter to the editor: Cautious use of multistate modeling in prognosis analysis of hepatocellular carcinoma.

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J Hepatol

Severe de novo liver injury after Moderna vaccination - not always autoimmune hepatitis.

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Gastroenterol

Abdominal CT scan before percutaneous gastrostomy tube placement.

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Correlation of Autoimmune Pancreatitis and Risk of Gastric Cancer in East Asian Population.

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Correspondence from Rashmi et al " Effect of Vitamin D Supplementation on Vitamin D Level and Bone Mineral Density in Patients With Cirrhosis: A Randomized Clinical Trial ".

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Shall we reduce endoscopy in patients with irritable bowel syndrome?

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Sleep position and reflux: Don't lose sleep over it.

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Snare Wire Diameter for the Efficacy of Cold Polypectomy: Are Our Conclusions Robust to Variations in the Judging Criteria?

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Surveillance after Treatment of Barrett's Esophagus Benefits Those with High-Grade Dysplasia or Intramucosal Cancer Most.

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The "Spoke Wheel" Sign in Splenic Dabska Tumor: A Case Report.

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Thirty brushing passes for malignant biliary stricture - the upper limit, or do we go higher?

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We should not forget about patients with inflammatory bowel disease who received a COVID-19 viral vector vaccine.

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Clin Gastroenterol Hepatol

Gossypiboma: an unexpected guest in the stomach.

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The effect of the Crohn's Disease Exclusion Diet (CDED) on patients with pouch inflammation: an interventional pilot study.

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Endoscopy

Application of intralesional traction assistance with traction wire to endoscopic submucosal dissection for colorectal neoplasms.

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Author commentary on Régis Souche et al.

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Author commentary on Veronique R. H. Van der Voort et al.

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Endoscopic treatment selection for superficial duodenal tumors: pay attention to small lesions.

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Letter to the editor re initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease.

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Reopenable clip over-the-line method with muscle layer grasping clips for large duodenal post-endoscopic submucosal dissection defects.

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Reply to Dr. Chung and colleagues.

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Reply to Lv and Yang.

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Gastroenterology

Stopping Surveillance in GI Conditions: Thoughts on the scope of the problem and potential solutions.

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Strengths and weaknesses of an artificial intelligence polyp detection program as assessed by a high detecting endoscopist.

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Gut

LOXL2 in pancreatic tumourigenesis: the complexity of tumour-stromal crosstalk exemplified.

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Inflamm Bowel Dis

Network Clinical Collaboration to Improve Quality of Care of Patients with Inflammatory Bowel Disease in China.

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Real-world short-term effectiveness of ustekinumab in Crohn's disease: Results from a multicenter prospective study in China.

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Virtual Chromoendoscopy vs High-definition White Light Endoscopy Using iSCAN.

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J Hepatol

From the Editor's Desk...

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