88 articles - From Saturday Apr 16 2022 to Friday Apr 22 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Aliment Pharmacol Ther |
meta-analyses and systematic reviews
| Gastroenterology |
Deep submucosal invasion is not an independent risk factor for lymph node metastasis in T1 colorectal cancer: a meta-analysis. DSI is not a strong independent predictor for LNM and should be reconsidered as a sole indicator for oncologic surgery. The expanding armamentarium for local excision as first-line treatment prompts serious consideration in amenable cases to tailor T1 CRC management. |
| Neurogastroenterol Motil |
Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux. A sequential treatment strategy, including head of bed elevation, prolonging dinner-to-bed time, promoting left lateral decubitus position and treatment with acid-suppressive medication is recommended for nocturnal gastroesophageal reflux symptoms. Currently, there is insufficient evidence for the use of nCPAP, hypnotics, baclofen and adding bedtime H2 receptor antagonists. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Safety of sequential biological therapy in inflammatory bowel disease: results from a tertiary referral Centre. This study shows that the sequential use of biological therapy in IBD does not seem to convey an overall higher risk of serious infections or malignancies, but that underlying more refractory disease seems to increase this risk. |
| Am J Gastroenterol |
Abnormal perception of urge to defecate: an important pathophysiological mechanism in women with chronic constipation. Abnormal urge perception was observed in 50% of women with CC, and was frequently described as abdominal sensation, supporting the concept that sensory dysfunction makes an important contribution to the pathophysiology of constipation. |
Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease (PRODUCE): A Series of N-of-1 Diet Trials. SCD and MSCD did not consistently improve symptoms or inflammation, although some individuals may have benefited. However, there are inherent difficulties in examining dietary changes that complicate study design and ultimately conclusions regarding effectiveness. |
The Role of Food in the Treatment of Bowel Disorders: Focus on Irritable Bowel Syndrome and Functional Constipation. Finally, we discuss the available efficacy data for fiber, other dietary interventions (e. g., Mediterranean diet, gluten-free diet, holistic dietary interventions), and functional foods (e. g., kiwifruit, rhubarb, aloe, prunes, etc.) in the management of IBS and FC. |
| Clin Gastroenterol Hepatol |
Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multi-center Inpatient Cirrhosis Cohort. In a multi-center inpatient cohort, admission serum metabolites, including thyroxine predicted advanced HE development independent of clinical factors. Admission low local laboratory thyroxine levels were validated as a predictor of advanced HE development in a separate cohort. |
Association of standardized radiology reporting and management of abdominal CT and MRI with diagnosis of pancreatic cancer. In this large quasi-experimental community-based observational study, implementation standardized reporting of abdominal CT and MRI reports with clinical navigation was effective for increasing the detection and diagnosis of pancreatic cancer. |
Screening HIV patients at risk for NAFLD using MRI-PDFF and transient elastography: a European multicenter prospective study. In a large cohort of HIV-moninfected patients at risk of NAFLD, steatosis is present in two third of cases and around 10% have AF. The CAP technique is accurate for screening steatosis in this population. |
| Gut |
FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression. FOXA2 replaces FXR to maintain MRP2 expression in ALF without sepsis. Ectopic FOXA2 expression to maintain MRP2 represents a potential strategy to prevent hyperbilirubinaemia in septic ALF. |
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma. Taken together, our findings establish novel pathophysiological roles and functions for LOXL2 in PDAC, which could be potentially exploited to treat metastatic disease. |
| Hepatology |
Identification of the Chloride Channel, Leucine-Rich Repeat-Containing Protein 8, subfamily A (LRRC8A), in Mouse Cholangiocytes. These results demonstrate that LRRC8A is functionally present in mouse BECs, contributes to volume-activated Cl - secretion, and therefore, may be a target to modulate bile formation in the treatment of cholestatic liver disorders. |
Neutralization and receptor usage of infectious culture derived rat hepacivirus as a model for hepatitis C. The RHV-rn1 infectious cell culture system enables studies of humoral immune responses against hepacivirus infection. Moreover, recapitulation of the entire RHV-rn1 infectious cycle in cell culture will facilitate reverse genetic studies and the exploration of tropism and virus-host interactions. |
Racial and ethnic disparities in early treatment with immunotherapy for advanced hepatocellular carcinoma in the United States. Immunotherapy was associated with improved OS compared to chemotherapy in advanced HCC. There are significant disparities in early access to immunotherapy, likely due to differential access to clinical trials and experimental therapies. A comprehensive approach to monitoring and eliminating racial-ethnic disparities in the management of advanced HCC is urgently needed. |
Relationship between non-alcoholic fatty liver disease and coronary artery disease: A Mendelian randomization study. The two-sample MR analyses showed a robust association between genetically predicted NAFLD and CAD after exclusion of genetic variants that are implicated in impaired VLDL secretion. |
| Inflamm Bowel Dis |
Accuracy of Serum Leucine-Rich Alpha-2 Glycoprotein in Evaluating Endoscopic Disease Activity in Crohn's Disease. Leucine-rich alpha-2 glycoprotein can be used in assessing endoscopic activity and is a reliable marker of endoscopic remission in CD patients. It can be an intermediate target in the treatment of CD. |
Assessment of the Degree of Variation of Histologic Inflammation in Ulcerative Colitis. We found minimal variability between degree of inflammation among biopsy fragments within and among different colorectal segments in UC, suggesting that even a single biopsy would adequately reflect the inflammation of the entire colorectum. These findings have significant implications for the use of histology as a clinical target and trial end point in UC. |
Histological Indices and Risk of Recurrence in Crohn's Disease: A Retrospective Study of a Cohort of Patients in Endoscopic Remission. Histological scores are valuable indicators to predict recurrence. Histological assessment of activity seems insufficient to predict CD course with most of the score evaluated, highlighting the need for new indices or adaptation of actual scores to CD specificities. |
| J Crohns Colitis |
The impact of vedolizumab and ustekinumab on articular extra-intestinal manifestations in inflammatory bowel disease patients: a real-life multicentric cohort study. Vedolizumab and ustekinumab can be used safely in patients with articular extra-intestinal manifestations. Only a temporary increased risk for developing arthralgia has been observed under vedolizumab. |
| J Hepatol |
Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial. In patients with mild-to-moderate fibrosis due to NASH, semaglutide with firsocostat and/or cilofexor was generally well tolerated. In exploratory efficacy analyses, treatment resulted in additional improvements in liver steatosis and biochemistry vs semaglutide alone. Given this was a small-scale open-label trial, double-blind placebo-controlled trials with adequate patient numbers to assess efficacy and safety of these combinations in NASH are warranted. |
Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma. This study identifies early predictors of clinical response to anti-PD-1 ICB in HCC patients and offers mechanistic insights into the immune trajectories of these immune subsets that interface between response and toxicity. We also propose a new combination immunotherapy for HCC to enhance response without exacerbating irAEs. |
| Neurogastroenterol Motil |
Guidewire-assisted placement of water-perfused esophageal high-resolution manometry probe when gastric insertion fails: A single-center experience. In cases of inability to traverse the EGJ, insertion of a water-perfused HRM probe using an endoscopically-placed nasogastric guidewire allows successful EGJ and esophageal peristalsis assessment. Although motility disorders are often suspected using alternative diagnostic modalities, guidewire-assisted placement of HRM may be helpful for revealing them in patients where alternative diagnostic modalities are either unavailable or inconclusive. |
Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension. IBS-C and FABD patients show reduced TI motility and differences in luminal content compared with HCs. This potentially indicates reflux of colonic contents or delayed clearance of the TI, which alongside increased ACD may contribute to symptoms of constipation and bloating. |
Metabotropic 5-HT receptor-mediated effects in the human submucous plexus. Background Serotonin (5-HT) is an important mediator in the gastrointestinal tract, acting on different neuronal 5-HT receptors. The ionotropic 5-HT receptors in the postsynaptic activation of human submucous neurons by 5-HT. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Gastroenterology |
| Gastrointest Endosc |
| Hepatology |
Alcohol use disorder in community management of chronic liver diseases. For those with hepatitis C or non-alcoholic fatty liver disease (NAFLD), alcohol use accelerates negative liver-related outcomes. In women, alcohol use accelerates liver damage and results in worsened liver-related mortality. Efforts to integrate AUD and liver disease care are urgently needed and can occur at several levels, with establishment of multidisciplinary ALD clinics for fully integrated co-management as an important goal. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| Gastroenterology |
| Gut |
| Hepatology |
| J Hepatol |
all remaining publications eg case reports, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gut |
| Inflamm Bowel Dis |
| J Hepatol |